According to research, the bacterium that causes Lyme disease, which is common to all bacteria, has a highly unusual modification in its molecular bag of defense.
The number of cases reported and the geographic distribution of Lyme disease in the United States have dramatically increased over the previous 20 years. The Lyme disease-causing bacterium Borrelia burgdorferiis carried by black-legged ticks that live in Virginia and bite humans. Jutras discovered in 2019 that after entering the human body, B. burgdorferireleases peptidoglycan. Even though peptidoglycan is present in all bacteria, many do not shed it. Different types of bacteria are the cause of Lyme disease. Its peptidoglycan and its constituent parts are made oddly. Chitin, a structural carbohydrate with bound sugar molecules made from modified glucose, is broken down into the sugar that B. burgdorferi incorporates into its peptidoglycan. Ticks must include chitin to survive. According to studies, B. burgdorferi’s peptidoglycan stays in the tissues of people with Lyme arthritis long after the bacteria has entered the body. The peptidoglycan is present weeks to months after the initial infection, causing pain and inflammation. A protein linked to Borrelia burgdorferi’s peptidoglycan was found in the lab. It acts as a molecular beacon that annoys the patients’ immune systems and amplifies inflammation in Lyme arthritis sufferers. Given that this is a very novel molecule, this discovery opens up an exciting new field of study for the lab. Researchers believe that these molecules are released by the bacterium, and this finding may pave the way for creating a diagnostic tool that looks for them, much like a biomarker for Lyme disease.
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Sources
Reference : [1] – “The unusual cell wall of the Lyme disease spirochaete Borrelia burgdorferi is shaped by a tick sugar | Nature Microbiology” . Accessed January 20, 2023. Link .