1837 | Theodore Schwann, a German physiologist first came up with a physio-chemical explanation of life and explained yeast multiplication in fermentation. |
1838 | Charles Cagniard Latour, a French physicist confirmed the role of yeast in fermentation. |
1840 | Jacob Henle, a German physician, pathologist, and anatomist came up with the concept of the germ theory of disease. |
1844 | Agostino Bassi stated the idea that not only animal but also human diseases are caused by other living microorganisms. |
1850 | Semmelweis, Hungarian physician discovered that the incidence of puerperal fever (also known as “childbed fever”) could be drastically cut by the use of hand disinfection in obstetrical clinics. Read More |
1860s | The germ theory of disease was proposed. However, evidence is insufficient to prove that microorganisms can cause several diseases. Confirmation of the role of microbes in fermentation. |
1862 | Ernst Haeckel was a German biologist explained that in an organism’s immune system, phagocytosis process occurs where certain foreign microorganisms (such as amoeba) attach to the cell surface either to destroy it or feed on it. Read More |
1867 | Joseph Lister invented aseptic practice in surgery using carbolic acid. This method has greatly improved surgical practice, especially in reducing infections and complications due to contaminations. |
1876 | Robert Koch, German microbiologist published the work on anthrax. Read More |
1877 | Paul Ehrlich, a German physician demonstrated that mast cells (a type of white blood cells) are an essential part of the immune and neuroimmune systems. |
1878 | The germ theory of disease was finally postulated by Louis Pasteur. This theory confirmed that some diseases are indeed caused by microorganisms. |
1880 | During this period, the theory of using the live bacterial virulence culture in the vaccines could act as immunity for chicken cholera and anthrax was proposed. |
1881 | Pasteur vaccinated 24 sheep, 1 goat, and 6 cows with five drops of the living attenuated anthrax bacillus. On May 17, he inoculated the animals with a less attenuated strain. On May 31, all of the animals received viable virulent anthrax bacilli. Additionally, 24 more sheep, 1 goat, and 3 cows received the virulent microorganism without the protection of the vaccination. On June 2, 1881, all non-vaccinated animals died while only two sheep of the protected group succumbed. One of the sheep had died due to pregnancy complications. |
1882 | Ilya Mechnikov (Russian Zoologist) successfully developed the first full theory of immunology. Robert Koch isolated the bacterium Mycobacterium tuberculosis and, as its name suggests, the causative agent of tuberculosis. Not long after, he discovered the bacterial origin of anthrax, the bacterium Bacillus anthracis (Microbiology 2006). The term “virus” (which originally meant poison) was used for the first time by Louis Pasteur. But despite this, he had no idea about its mechanism of infection. In the same year, he also discovered that antibodies are responsible for immunity. |
1885 | Louis Pasteur discovered the method to treat germ-borne diseases like tuberculosis, anthrax, and cholera. In honor of Jenner’s initial discovery of the smallpox vaccine, Pasteur called his treatment vaccination (Microbiology 2006). |
1886 | Louis Pasteur also developed the process now known as pasteurization. In this process, the liquid is boiled and then cooled to kill the bacteria that cause the souring of milk and other beverages.In the same year, Theobold Smith (an American microbiologist) demonstrated that heat actually killed cultures of chicken cholera bacillus and was also effective in protection from cholera. This proved that the microorganisms did not have to be viable to induce the protection. |
1888 | Roux and Yersin discovered the diphtheria toxin. Read More |
1890 | Von Behring and Kitasato demonstrated the presence of anti-toxin in the blood of individuals recovering from diphtheria. Von Behring was the first to use this antiserum in treating active disease. The forerunner to what we call “serotherapy” today. Read More |
1891 | Robert Koch demonstrated the cutaneous hypersensitivity. Read More |
1892 | Dmitri Iwanowski provided the very first concrete evidence for the existence of a virus. He discovered that tobacco mosaic disease is caused by a virus which is a non-bacterial infectious agent. Unlike bacteria, viruses are capable of passing through fine-pored filters like porcelain and diatomite. |
1893 | William Coley, an American cancer researcher and bone surgeon discovered a toxin (named after him – Coley’s Toxins) which is a combination of live bacteria and bacterial lysates to treat tumors. |
1894 | Richard Pfeiffer, German physician, and bacteriologist found that live cholera bacteria could be injected without ill effects into guinea pigs previously immunized against cholera and that blood plasma from these animals added to live cholera bacteria caused them to become motionless and to lyse. This could be inhibited by previously heating the blood plasma. He called this bacteriolysis known as the Pfeiffer Phenomenon or Isayev-Pfeiffer phenomenon. Read More |
1895 to early 1900 | Immunology was preoccupied with the definition of the cellular (Elie Metchnikoff’s phagocytosis theory) as opposed to the humoral basis of the bactericidal defense. “Cellularists” believed that phagocytes, rather than antibodies, played the leading role in immunity. On the other hand, the “Humoralists” believed that a soluble substance in the body was mainly responsible for mediating immunity (n.a., Microbiology in 20th Century 2011). |
1896 | Jules Bordet, Belgian immunologist and microbiologist described an antibacterial, heat-labile serum component. Read More |